Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 16/20 | 0.34 |
| ▸ | CCNH | P51946 | 15/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 15/20 | 0.34 |
| ▸ | CDK9 | P50750 | 10/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.34 |
| ▸ | CCNK | O75909 | 8/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184308 | 0.70 | CDK7 (0.55) | CDK7CCNHMNAT1CDK9CCNT1 | |
| SCHEMBL21184588 | 0.66 | CCNK (0.46) | CDK7CCNHMNAT1CDK9CCNT1 | |
| SCHEMBL21184424 | 0.63 | FLT3 (0.36) | CDK7CCNHMNAT1CDK9CCNT1 | |
| SCHEMBL21026771 | 0.59 | CDK9 (0.57) | CDK7CCNHMNAT1CDK9CCNT1 | |
| SCHEMBL28933583 | 0.58 | PAK1 (0.47) | CDK7CDK9ADORA1CDK4CCND1 | |
| SCHEMBL25043383 | 0.56 | MEN1 (0.40) | — | |
| SCHEMBL9704728 | 0.56 | PDE4A (0.43) | CDK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL9704732 | 0.55 | PAK1 (0.53) | CCNE1CDK2CDK4CCND1CCND2 | |
| SCHEMBL27428231 | 0.55 | NUDT1 (0.35) | CDK7CCNHMNAT1CDK9CCNT1 | |
| SCHEMBL20814607 | 0.55 | PDE4A (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |