Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11817511 | 0.87 | KDM4E (0.56) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL29112760 | 0.84 | PIM1 (0.60) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL7116996 | 0.84 | METAP2 (0.53) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL6305713 | 0.81 | KMT2A (0.50) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL3227590 | 0.81 | METAP2 (0.57) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL29222729 | 0.80 | KDM4E (0.53) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL1832253 | 0.78 | CYP1A2 (0.41) | KDM4EKMT2APIM1ALOX12ALDH1A1 | |
| SCHEMBL377165 | 0.78 | KDM4E (0.44) | KDM4EKMT2AMETAP2ALDH1A1CYP1A2 | |
| SCHEMBL1043719 | 0.78 | METAP2 (0.58) | KDM4EKMT2APIM1METAP2PLAU | |
| SCHEMBL4624293 | 0.77 | KDM4E (0.49) | KDM4EKMT2APIM1METAP2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2012-04-19 | — | — | US | disclosed |
| EP-2250152-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106586-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |
| EP-1185869-B1 | LIGAND-ANCHOR CONJUGATES FOR PRODUCING A BIOSENSOR LAYER | GRAFFINITY PHARMACEUTICALS AG (DE) | 2006-07-26 | — | — | EP | disclosed |
| US-3936452-A | Process of producing pyrimidyl thiocarbonates | NITTO BOSEKI CO., LTD. (JA) | 1976-02-03 | — | — | US | disclosed |
| US-3932375-A | PROTECTING GROUPS | NITTO BOSEKI CO. LTD. (JA) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | FDPS, GGPS1, CTPS1 | KDM4E 2805/4885KMT2A 3963/4885PIM1 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.