Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | METAP2 | P50579 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227590 | 0.87 | METAP2 (0.57) | KDM4EKMT2AMETAP2PLAUNCF1 | |
| SCHEMBL4626479 | 0.85 | ALDH1A1 (0.47) | KDM4EKMT2AMETAP2PLAUNCF1 | |
| SCHEMBL16511924 | 0.83 | MAP4K4 (0.54) | KDM4EKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6993187 | 0.79 | MAP4K4 (0.45) | ALDH1A1MAP4K4PIM1PIM2TSHR | |
| SCHEMBL15228636 | 0.79 | BACE1 (0.49) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15228726 | 0.79 | DHODH (0.49) | KDM4EKMT2AALOX12ALDH1A1MAP4K4 | |
| SCHEMBL4625590 | 0.78 | MEN1 (0.56) | KDM4EKMT2AMETAP2PLAUNCF1 | |
| SCHEMBL2118479 | 0.77 | KDM4E (0.59) | KDM4EKMT2AMETAP2PLAUNCF1 | |
| SCHEMBL4624601 | 0.77 | KMT2A (0.48) | KDM4EKMT2AMETAP2PLAUNCF1 | |
| SCHEMBL1043719 | 0.77 | METAP2 (0.58) | KDM4EKMT2AMETAP2PLAUNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501801-B1 | 2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF VLA-4 DEPENDENT DISEASES | UCB PHARMA SA (BE) | 2008-01-23 | — | — | EP | claimed |