Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.69 |
| ▸ | PAK4 | O96013 | 3/20 | 0.69 |
| ▸ | CDK2 | P24941 | 3/20 | 0.69 |
| ▸ | CLK2 | P49760 | 3/20 | 0.69 |
| ▸ | CDK7 | P50613 | 3/20 | 0.69 |
| ▸ | PRKX | P51817 | 3/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.69 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.69 |
| ▸ | MELK | Q14680 | 3/20 | 0.69 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.69 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.69 |
| ▸ | FLT3 | P36888 | 2/20 | 0.69 |
| ▸ | GSK3A | P49840 | 2/20 | 0.69 |
| ▸ | JAK2 | O60674 | 2/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | PRKACA | P17612 | 2/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22566549 | 0.88 | TSHR (0.63) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL22566548 | 0.88 | TSHR (0.62) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL22566519 | 0.87 | HDAC3 (0.70) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL22566619 | 0.87 | HDAC3 (0.58) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL21185375 | 0.84 | TSHR (0.65) | ALOX15TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL22566562 | 0.80 | HDAC3 (0.60) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL28721392 | 0.80 | TSHR (0.49) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL28721391 | 0.80 | TSHR (0.49) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL22566338 | 0.79 | GPR55 (0.55) | CDC7DAPK3PAK4CDK2CLK2 | |
| SCHEMBL19708171 | 0.78 | MEN1 (0.78) | CDC7DAPK3PAK4CDK2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| US-11639345-B2 | Methionine metabolic pathway inhibitors | MIGAL—GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-05-02 | — | — | US | disclosed |
| US-11639345-B2 | Methionine metabolic pathway inhibitors | MIGAL—GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-05-02 | — | — | US | disclosed |
| US-20200331872-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2020-10-22 | — | — | US | disclosed |
| WO-2019142192-A1 | NEW METHIONINE METABOLIC PATHWAY INHIBITORS | GAVISH-GALILEE BIO APPLICATIONS LTD. (IL) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639345-B2 | Methionine metabolic pathway inhibitors | GSS, MTR, CTH | CDC7 1348/4885DAPK3 3140/4885PAK4 1785/4885 |
| US-20200331872-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | GSS, MTR, CTH | CDC7 1348/4885DAPK3 3140/4885PAK4 1785/4885 |
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | GSS, MTR, CTH | CDC7 1348/4885DAPK3 3140/4885PAK4 1785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.