Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30399809 | 0.87 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4719832 | 0.87 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL26647446 | 0.83 | MAPT (0.46) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL24455822 | 0.81 | TXNRD1 (0.43) | MAPTALDH1A1LMNATXNRD1SMN1; SMN2 | |
| SCHEMBL9327435 | 0.79 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL4594918 | 0.79 | MAPT (0.46) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL26087355 | 0.77 | CHEK1 (0.43) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL8564000 | 0.77 | ALDH1A1 (0.53) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1559236 | 0.77 | NNMT (0.47) | MAPTALDH1A1TXNRD1SMN1; SMN2MEN1 | |
| SCHEMBL3449492 | 0.76 | HCAR3 (0.46) | MAPTALDH1A1LMNATXNRD1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141549-A9 | 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 | ADAMED PHARMA S.A. (PL) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019141549-A1 | 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 | ADAMED PHARMA S.A. (PL) | 2019-07-25 | — | — | WO | disclosed |