SCHEMBL21187472

SCHEMBL21187472

C#CCOc1ccc2c(c1)ncn2-c1ccnc(Cl)c1-c1ccc(F)cc1Cl

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 12/20 0.33
▸ SRC P12931 6/20 0.33
▸ TP53 P04637 1/20 0.31
▸ MAPK14 Q16539 2/20 0.31
▸ HSD11B1 P28845 1/20 0.31
▸ MAPK13 O15264 1/20 0.30
▸ MAPK12 P53778 1/20 0.30
▸ MAPK11 Q15759 1/20 0.30
▸ SLC5A2 P31639 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21187473 0.83 FGFR1 (0.34) FGFR1SRCHSD11B1
SCHEMBL21187475 0.74 HSD11B1 (0.36) MAPK14HSD11B1MAPK13MAPK12MAPK11
SCHEMBL21187456 0.74 MAPK14 (0.36) MAPK14HSD11B1MAPK13MAPK12MAPK11
SCHEMBL21187457 0.72 MAOB (0.32) MAPK14
SCHEMBL21187508 0.72 HSD11B1 (0.37) FGFR1TP53HSD11B1
SCHEMBL22599086 0.70 EPAS1 (0.34) TP53MAPK14
SCHEMBL21187470 0.69 PTGS1 (0.40) FGFR1
SCHEMBL21187448 0.67 FGFR1 (0.44) FGFR1TP53MAPK14HSD11B1MAPK13
SCHEMBL21187447 0.67 FGFR1 (0.44) FGFR1TP53HSD11B1
SCHEMBL21187436 0.65 KMT2A (0.49) FGFR1SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3740474-B1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2022-01-05 — — EP disclosed
US-20200339543-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2020-10-29 — — US disclosed
WO-2019141972-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-07-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339543-A1 AGRICULTURAL CHEMICALS ABAT, BRDT, GABBR1 FGFR1 2730/4885SRC 2767/4885TP53 2470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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