SCHEMBL21187473

SCHEMBL21187473

C#CCOc1ccc2c(c1)ncn2-c1nccc(C)c1-c1ccc(F)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 12/20 0.34
▸ HSD11B1 P28845 2/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ DPP4 P27487 1/20 0.33
▸ MKNK2 Q9HBH9 1/20 0.33
▸ SRC P12931 5/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21187472 0.83 FGFR1 (0.33) FGFR1HSD11B1SRC
SCHEMBL21187471 0.76 HSD11B1 (0.39) HSD11B1DPP4
SCHEMBL21187498 0.76 HSD11B1 (0.39) HSD11B1DPP4
SCHEMBL21187485 0.73 EGFR (0.33) HSD11B1ALDH1A1
SCHEMBL20698297 0.68 FGFR1 (0.43) FGFR1HSD11B1ALDH1A1MAPTSMN1; SMN2
SCHEMBL21187448 0.68 FGFR1 (0.44) FGFR1HSD11B1KCNH2DPP4MKNK2
SCHEMBL21187447 0.68 FGFR1 (0.44) FGFR1HSD11B1MAPT
SCHEMBL21187436 0.66 KMT2A (0.49) FGFR1SRCALDH1A1MAPTSMN1; SMN2
SCHEMBL21187476 0.65 HSD11B1 (0.43) HSD11B1
SCHEMBL21187438 0.64 HSD11B1 (0.42) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3740474-B1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2022-01-05 — — EP disclosed
US-20200339543-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2020-10-29 — — US disclosed
WO-2019141972-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-07-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339543-A1 AGRICULTURAL CHEMICALS ABAT, BRDT, GABBR1 FGFR1 2730/4885HSD11B1 930/4885KCNH2 1812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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