Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6435477 | 0.97 | ALDH1A1 (0.79) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL7937801 | 0.91 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL31272367 | 0.90 | ALDH1A1 (0.83) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL215570 | 0.89 | ALDH1A1 (0.94) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL9431044 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL28196017 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL28044779 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRLMNAALOX15 | |
| Citric Acid SCHEMBL31223219 | 0.87 | ALDH1A1 (0.79) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL226489 | 0.87 | ALDH1A1 (0.79) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL437150 | 0.87 | ALDH1A1 (0.79) | ALDH1A1KDM4ETSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110621748-A | Ink composition for inkjet printing | 多米诺印刷科学有限公司 | 2019-12-27 | — | — | CN | claimed |
| US-12104098-B2 | Self-sealing tires | DOW SILICONES CORPORATION (US) | 2024-10-01 | — | — | US | disclosed |
| US-20230106847-A1 | SELF-SEALING TIRES | DOW SILICONES CORPORATION | 2023-04-06 | — | — | US | disclosed |
| EP-4041820-B1 | SELF-SEALING TIRES | DOW SILICONES CORP (US) | 2023-03-01 | — | — | EP | disclosed |
| EP-4041820-A1 | SELF-SEALING TIRES | Dow Silicones Corporation (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-109476919-B | Elastomer composition and use thereof | 美国陶氏有机硅公司 | 2021-08-24 | — | — | CN | disclosed |
| WO-2021071847-A1 | SELF-SEALING TIRES | DOW SILICONES CORPORATION (US) | 2021-04-15 | — | — | WO | disclosed |
| CN-110621748-A | Ink composition for inkjet printing | 多米诺印刷科学有限公司 | 2019-12-27 | — | — | CN | disclosed |
| US-8951363-B2 | Anti-corrosive treatment for surfaces made of zinc and zinc alloys | ATOTECH DEUTSCHLAND GMBH (DE) | 2015-02-10 | — | — | US | disclosed |
| US-20120091398-A1 | ANTI-CORROSIVE TREATMENT FOR SURFACES MADE OF ZINC AND ZINC ALLOYS | ATOTECH USA, LLC | 2012-04-19 | — | — | US | disclosed |