Citric Acid

Citric Acid

SCHEMBL6435477

CCCC.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.45
ALDH1A1 P00352 2/20 0.79
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.47
KDM4E B2RXH2 2/20 0.47
LMNA P02545 2/20 0.47
MAPT P10636 1/20 0.47
ALOX15 P16050 1/20 0.47
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
CYP1A2 P05177 1/20 0.45
KMT2A Q03164 1/20 0.45
SLC13A5 Q86YT5 3/20 0.42
HSPD1 P10809 1/20 0.40
BLM P54132 1/20 0.40
HSPE1 P61604 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL2118949 0.97 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7937801 0.93 ALDH1A1 (0.68) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL31272367 0.92 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL9431044 0.90 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28044779 0.90 ALDH1A1 (0.71) ALDH1A1TSHRKDM4ELMNAALOX15
Citric Acid SCHEMBL28196017 0.90 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL31223216 0.90 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL226489 0.90 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL437150 0.90 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL31223219 0.90 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106267220-B Gualfenesin dextromethorphan hydrobromide is anhydrous to swallow taste masking preparation 北京科信必成医药科技发展有限公司 2019-06-28 CN claimed
CN-102470080-B Catalysed dye systems 利兹大学 2017-08-29 CN claimed
CN-102470080-A Catalyzed Dye System UNIV LEEDS 2012-05-23 CN claimed
CN-118497003-A Aspergillus tubingensis and application thereof 丰益(上海)生物技术研发中心有限公司 2024-08-16 CN disclosed
EP-4076045-B1 METHOD FOR MANUFACTURING A FILTER MATERIAL AND/OR FILLER MATERIAL FOR MOUTHPIECES FOR USE WITH SMOKING PRODUCTS OR HNB PRODUCTS, MOUTHPIECES AND CIGARETTE FILTERS COMPRISING SUCH A FILTER MATERIAL AND/OR FILLER MATERIAL CERDIA INT GMBH (CH) 2023-11-15 EP disclosed
EP-4076045-A1 FILTER MATERIAL AND/OR FILLER MATERIAL FOR MOUTHPIECES FOR USE WITH SMOKING PRODUCTS OR HNB PRODUCTS, MOUTHPIECES AND CIGARETTE FILTERS COMPRISING SUCH A FILTER MATERIAL AND/OR FILLER MATERIAL, AND METHOD FOR MANUFACTURING SUCH A FILTER MATERIAL AND/OR FILLER MATERIAL Cerdia International GmbH (CH) 2022-10-26 EP disclosed
WO-2021121839-A1 FILTER MATERIAL AND/OR FILLER MATERIAL FOR MOUTHPIECES FOR USE WITH SMOKING PRODUCTS OR HNB PRODUCTS, MOUTHPIECES AND CIGARETTE FILTERS COMPRISING SUCH A FILTER MATERIAL AND/OR FILLER MATERIAL, AND METHOD FOR MANUFACTURING SUCH A FILTER MATERIAL AND/OR FILLER MATERIAL Cerdia International GmbH (CH) 2021-06-24 WO disclosed
CN-104884552-B The curable coating composition of one pack system, its preparation and application and coating prepared therefrom and product 巴斯夫涂料有限公司 2018-09-14 CN disclosed
CN-108083334-A A kind of preparation method of monodisperse spherical nano zirconium dioxide powder body material 长江大学 2018-05-29 CN disclosed
CN-105358626-B Conductive polyamide composition and article 沙特基础全球技术有限公司 2017-11-24 CN disclosed
CN-102470080-B Catalysed dye systems 利兹大学 2017-08-29 CN disclosed
CN-102906013-A Method for preparing highly porous stable metal oxides with controlled pore structure UNIV BRIGHAM YOUNG 2013-01-30 CN disclosed
CN-102553656-A Catalyst and method of manufacture GEN ELECTRIC 2012-07-11 CN disclosed
CN-102527379-A Catalyst and method of manufacture GEN ELECTRIC 2012-07-04 CN disclosed
CN-102470080-A Catalyzed Dye System UNIV LEEDS 2012-05-23 CN disclosed
CN-102341440-A Thermoplastic molded article having a metal layer DU PONT 2012-02-01 CN disclosed
CN-101743373-A Sealant for insulating glass unit DOW CORNING 2010-06-16 CN disclosed
CN-1946833-A Lubricant and fuel compositions containing hydroxy polycarboxylic acid esters CHEMTURA CORP (US) 2007-04-11 CN disclosed
US-20050077648-A1 Solution casting method and polymer film FUJIFILM CORPORATION (JP) 2005-04-14 US disclosed
CN-1354777-A Agricultural mulch film capable of initiating degradation EASTMAN CHEM CO (US) 2002-06-19 CN disclosed