Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2106649 | 0.87 | HPGD (0.55) | SMN1; SMN2MEN1KMT2AHPGDUSP2 | |
| SCHEMBL30033208 | 0.87 | HPGD (0.55) | SMN1; SMN2MEN1KMT2AHPGDUSP2 | |
| SCHEMBL30032014 | 0.85 | HPGD (0.58) | SMN1; SMN2MEN1KMT2AHPGDUSP2 | |
| SCHEMBL3342742 | 0.83 | HPGD (0.51) | SMN1; SMN2MEN1KMT2AHPGDUSP2 | |
| SCHEMBL6422572 | 0.81 | TSHR (0.71) | HPGDUSP2MAPTTSHRPOLB | |
| SCHEMBL22767193 | 0.80 | HPGD (0.55) | MEN1KMT2AHPGDUSP2ALDH1A1 | |
| SCHEMBL21189714 | 0.80 | HPGD (0.58) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL6366439 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL155189 | 0.80 | KMT2A (0.56) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL21179375 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141694-A1 | PI4KIIIBETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-25 | — | — | WO | disclosed |