Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2798855 | 0.86 | HPGD (0.46) | TSHRHPGDUSP2POLBKMT2A | |
| SCHEMBL21189725 | 0.86 | KMT2A (0.50) | TSHRLMNATP53HPGDPOLB | |
| SCHEMBL12795963 | 0.84 | TSHR (0.49) | TSHRLMNAHPGDUSP2POLB | |
| SCHEMBL21177358 | 0.83 | RORC (0.40) | TSHRLMNATP53ALOX15KDM4E | |
| SCHEMBL21177360 | 0.83 | RORC (0.40) | TSHRLMNATP53ALOX15KDM4E | |
| SCHEMBL24340135 | 0.83 | HSP90AA1 (0.43) | TSHRLMNAKDM4EHPGDUSP2 | |
| SCHEMBL21189459 | 0.82 | KMT2A (0.53) | TSHRLMNAHPGDPOLBKMT2A | |
| SCHEMBL2800290 | 0.80 | MAPT (0.51) | TSHRLMNAKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1721722 | 0.79 | ALDH1A1 (0.47) | LMNATP53KDM4EPOLBKMT2A | |
| SCHEMBL24745868 | 0.79 | HPGD (0.56) | TSHRLMNAHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141694-A1 | PI4KIIIBETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-25 | — | — | WO | disclosed |