Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPD | P32754 | 7/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31463104 | 0.81 | NPC1 (0.71) | POLBHSD17B10NPC1HPDGRM1 | |
| SCHEMBL29110427 | 0.78 | POLB (0.73) | POLBHSD17B10NPC1HPDGRM1 | |
| SCHEMBL30089869 | 0.78 | POLB (0.73) | POLBHSD17B10NPC1HPDGRM1 | |
| SCHEMBL8307781 | 0.77 | POLB (0.71) | POLBNPC1HPDGRM1L3MBTL1 | |
| SCHEMBL29110466 | 0.75 | HSD17B10 (0.72) | POLBHSD17B10HPDL3MBTL1 | |
| SCHEMBL30089880 | 0.75 | HSD17B10 (0.72) | POLBHSD17B10HPDL3MBTL1 | |
| SCHEMBL7168172 | 0.75 | MAPT (0.58) | POLBHSD17B10NPC1HPDGRM1 | |
| SCHEMBL31196714 | 0.75 | POLB (0.61) | POLBHSD17B10NPC1HPDGRM1 | |
| SCHEMBL31196718 | 0.75 | HPD (0.61) | POLBHSD17B10NPC1HPDGRM1 | |
| SCHEMBL29110419 | 0.75 | POLB (0.77) | POLBHSD17B10NPC1HPDGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350085-B1 | QUINAZOLINONE LINKED PYRROLO[2,1 -C][1.4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-06-19 | — | — | EP | disclosed |
| US-20120095214-A1 | QUINAZOLINONE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-04-19 | — | — | US | disclosed |
| EP-2350085-A1 | QUINAZOLINONE LINKED PYRROLOÝ2,1 -C¨Ý1.4¨BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF | Council Of Scientific & Industrial Research (IN) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010058416-A1 | QUINAZOLINONE LINKED PYRROLO[2,1 -C][1.4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095214-A1 | QUINAZOLINONE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | GABRA1, CYP2C19, GABRA5 | POLB 1520/4885HSD17B10 1361/4885NPC1 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.