Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 2/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3785373 | 0.84 | HTR7 (0.61) | HTR7NPC1ATMALOX5APFEN1 | |
| SCHEMBL3789854 | 0.81 | HTR7 (0.46) | HTR7NPC1ATMALOX5APFEN1 | |
| SCHEMBL30958568 | 0.80 | NPC1 (0.47) | HTR7NPC1ATMALOX5APFEN1 | |
| SCHEMBL2122528 | 0.79 | ALDH1A1 (0.44) | HTR7NPC1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL8588225 | 0.78 | ALDH1A1 (0.48) | HTR7NPC1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL7714839 | 0.76 | HTR7 (0.45) | HTR7NPC1ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL5050088 | 0.74 | ALOX5AP (0.46) | HTR7NPC1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL22892608 | 0.74 | KMT2A (0.40) | NPC1ALDH1A1MAPK1SMN1; SMN2BCHE | |
| SCHEMBL19125933 | 0.72 | ALDH1A1 (0.63) | NPC1ALDH1A1MAPK1SMN1; SMN2SLC6A3 | |
| SCHEMBL7522172 | 0.72 | ALDH1A1 (0.63) | NPC1ALDH1A1MAPK1SMN1; SMN2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155004-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-12-18 | — | — | US | disclosed |
| US-9717739-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-08-01 | — | — | US | disclosed |
| US-20170202857-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-20 | — | — | US | disclosed |
| US-20150342962-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER IP GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-8278469-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20120149670-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-14 | — | — | US | disclosed |
| US-20120094969-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155004-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | CYP19A1, SHBG, HSD17B11 | HTR7 789/4885NPC1 4350/4885ATM 3341/4885 |
| US-20170202857-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | HTR7 789/4885NPC1 4350/4885ATM 3341/4885 |
| US-20150342962-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | HTR7 789/4885NPC1 4350/4885ATM 3341/4885 |
| US-20120094969-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | HTR7 789/4885NPC1 4350/4885ATM 3341/4885 |
| US-20120149670-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | HTR7 789/4885NPC1 4350/4885ATM 3341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.