Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25349904 | 0.65 | APP (0.51) | KDM4ELMNAAPPCRBNTDP1 | |
| SCHEMBL23768390 | 0.65 | MAPT (0.40) | KDM4ELMNATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22276635 | 0.64 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1HPGDCYP2C9CYP2C19 | |
| SCHEMBL23713447 | 0.64 | KDM4E (0.35) | KDM4ELMNATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL31476875 | 0.64 | WDR5 (0.38) | KDM4ELMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1353069 | 0.63 | APP (0.67) | KDM4EAPPTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15071342 | 0.63 | APP (0.67) | KDM4EAPPTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7911522 | 0.63 | APP (0.67) | KDM4EAPPTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5930961 | 0.63 | APP (0.67) | KDM4EAPPTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7559918 | 0.62 | TDP1 (0.51) | TDP1SMN1; SMN2ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148055-A9 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019148055-A1 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-08-01 | — | — | WO | disclosed |