Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL6398929 | 1.00 | TSHR (0.47) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL40031 | 1.00 | TSHR (0.47) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL9690765 | 0.96 | TSHR (0.48) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL27971531 | 0.94 | SMN1; SMN2 (0.50) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL21496132 | 0.92 | SMN1; SMN2 (0.44) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL27783416 | 0.92 | TSHR (0.54) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Hexane SCHEMBL28954127 | 0.91 | ALDH1A1 (0.58) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL27396281 | 0.90 | SMN1; SMN2 (0.46) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL1946788 | 0.89 | TSHR (0.52) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Isopropyl Alcohol SCHEMBL27564110 | 0.89 | TSHR (0.52) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034432-B2 | Method for producing a swelling nonwoven fabric | BASF SE (DE) | 2015-05-19 | — | — | US | claimed |
| US-20120094566-A1 | METHOD FOR PRODUCING A SWELLING NONWOVEN FABRIC | BASF SE (DE) | 2012-04-19 | — | — | US | claimed |
| US-9499657-B2 | Binder for granular and/or fibrous substrates | BASF SE (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9034432-B2 | Method for producing a swelling nonwoven fabric | BASF SE (DE) | 2015-05-19 | — | — | US | disclosed |
| US-20120094566-A1 | METHOD FOR PRODUCING A SWELLING NONWOVEN FABRIC | BASF SE (DE) | 2012-04-19 | — | — | US | disclosed |
| US-20110294926-A1 | BINDER FOR GRANULAR AND/OR FIBROUS SUBSTRATES | BASF SE (DE) | 2011-12-01 | — | — | US | disclosed |
| EP-0199564-B1 | POLYHYDROXY POLYETHER, PROCESS FOR ITS PRODUCTION AND ITS USE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| EP-0199564-A2 | Polyhydroxy polyether, process for its production and its use | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-10-29 | — | — | EP | disclosed |