Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL6398929 | 0.96 | TSHR (0.47) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Propylene Glycol SCHEMBL2120984 | 0.96 | TSHR (0.47) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Propylene Glycol SCHEMBL40031 | 0.96 | TSHR (0.47) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Propylene Glycol SCHEMBL27971531 | 0.90 | SMN1; SMN2 (0.50) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Propylene Glycol SCHEMBL21496132 | 0.89 | SMN1; SMN2 (0.44) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Propylene Glycol SCHEMBL27783416 | 0.88 | TSHR (0.54) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Hexane SCHEMBL28954127 | 0.87 | ALDH1A1 (0.58) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Propylene Glycol SCHEMBL27396281 | 0.86 | SMN1; SMN2 (0.46) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| Glycerin SCHEMBL21799135 | 0.86 | ALDH1A1 (0.45) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL1946788 | 0.85 | TSHR (0.52) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089464-A | Release agent is oxyalkylene oligomer modified by a silane coupling agent | NISSHINBO INDUSTRIES, INC. (JP) | 1992-02-18 | — | — | US | claimed |
| US-10435583-B2 | Curing agent for epoxy resins, and epoxy resin composition obtained using same | DIC CORPORATION (JP) | 2019-10-08 | — | — | US | disclosed |
| US-20180327629-A1 | CURING AGENT FOR EPOXY RESINS, AND EPOXY RESIN COMPOSITION OBTAINED USING SAME | DIC CORPORATION (JP) | 2018-11-15 | — | — | US | disclosed |