Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL6398929 | 1.00 | TSHR (0.47) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL2120984 | 1.00 | TSHR (0.47) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL9690765 | 0.96 | TSHR (0.48) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL27971531 | 0.94 | SMN1; SMN2 (0.50) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL21496132 | 0.92 | SMN1; SMN2 (0.44) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL27783416 | 0.92 | TSHR (0.54) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Hexane SCHEMBL28954127 | 0.91 | ALDH1A1 (0.58) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Propylene Glycol SCHEMBL27396281 | 0.90 | SMN1; SMN2 (0.46) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL1946788 | 0.89 | TSHR (0.52) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| Isopropyl Alcohol SCHEMBL27564110 | 0.89 | TSHR (0.52) | TSHRMAPK1SMN1; SMN2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14269 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122079933-A | Bio-based epoxy resin, preparation method thereof and high-sealing environment-friendly anticorrosive paint | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137724-A1 | COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING LIGAMENT OR TENDON DISEASES | HANS BIOMED CORP (KR) | 2026-05-21 | — | — | US | claimed |
| CN-122060146-A | Yellowing-resistant epoxy resin curing agent and preparation method and application thereof | 广东电网有限责任公司电力科学研究院 | 2026-05-19 | — | — | CN | claimed |
| EP-4131549-B1 | CAPSULE FOR LITHIUM-SULFUR SECONDARY BATTERY, AND LITHIUM-SULFUR SECONDARY BATTERY COMPRISING SAME | LG ENERGY SOLUTION LTD (KR) | 2026-05-13 | — | — | EP | claimed |
| CN-122011641-A | Antibacterial super absorbent resin and preparation method and application thereof | 万华化学集团股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12612537-B2 | Thermosetting adhesive sheet and sub-gasket for fuel cell | HIGASHIYAMA FILM CO., LTD. (JP) | 2026-04-28 | — | — | US | claimed |
| US-12576185-B2 | Hyaluronic acid filler having high viscoelasticity and high cohesiveness | LYV Sciences Co., Ltd. (KR) | 2026-03-17 | — | — | US | claimed |
| US-12576353-B2 | Positively charged filter material with ability for removing charged particles efficiently, and method for producing same | TORAY ADVANCED MATERIALS KOREA INC. (KR) | 2026-03-17 | — | — | US | claimed |
| US-12562436-B2 | Separator and lithium battery employing same | SAMSUNG SDI CO., LTD. (KR) | 2026-02-24 | — | — | US | claimed |
| US-12552920-B2 | Environmentally friendly impregnation systems for fiber surface treatment and preparation methods thereof and an impregnation treatment method | BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY (CN) | 2026-02-17 | — | — | US | claimed |
| US-4948508-A | SURFACE TREATMENT OF AROMATIC HYDROPHOBIC POLYMER WITH EPOXIDE, FRIEDEL-CRAFTS CATALYST | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1990-08-14 | — | — | US | claimed |
| EP-0363545-A1 | A deodorant composition in the form of gel | AIKOH CO. LTD. (JP) | 1990-04-18 | — | — | EP | claimed |
| EP-0140377-B1 | POLYAMIDE-RUBBER BLENDED COMPOSITION | TOYODA GOSEI CO., LTD. (JP) | 1990-01-03 | — | — | EP | claimed |
| US-4567235-A | CARBOXYLATED ACRYLONITRILE-BUTADIENE COPOLYMER OR EPICHLOROHYDRIN | TOYODA GOSEI CO., LTD. (JP) | 1986-01-28 | — | — | US | claimed |
| US-4521565-A | Aqueous dispersion | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1985-06-04 | — | — | US | claimed |
| EP-0140377-A2 | Polyamide-rubber blended composition | TOYODA GOSEI CO., LTD. (JP) | 1985-05-08 | — | — | EP | claimed |
| US-4339500-A | Hydrophilic packing material for chromatography | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1982-07-13 | — | — | US | claimed |
| US-4190567-A | Aqueous cationic polyurethane emulsion with glycidyl ether curing agent | KAO SOAP CO., LTD. (JP) | 1980-02-26 | — | — | US | claimed |
| US-4032482-A | FROM A POLY-N-SUBSTITUTED POLYAMINE OR POLYALKYLENIMINE-EPOXY COMPOUND PREPOLYMER | MIYOSHI YUSHI KABUSHIKI KAISHA (JA) | 1977-06-28 | — | — | US | claimed |
| US-4026831-A | ADHESIVES, PAINT RESINS, ELECTROSTATIC INHIBITORS, RUST INHIBITORS | MIYOSHI YUSHI KABUSHIKI KAISHA (JA) | 1977-05-31 | — | — | US | claimed |