Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL21496132 | 0.94 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL40031 | 0.90 | TSHR (0.47) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL6398929 | 0.90 | TSHR (0.47) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL2120984 | 0.90 | TSHR (0.47) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL27971531 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL27783416 | 0.86 | TSHR (0.54) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL9690765 | 0.86 | TSHR (0.48) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Alcohol SCHEMBL28506337 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Hexane SCHEMBL28954127 | 0.85 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| Propylene Glycol SCHEMBL27930336 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080792-C | Modifier for quality of paper surface | NIPPON PMC KK (JP) | 2002-03-13 | — | — | CN | disclosed |
| CN-1137085-A | Modifier for quality of paper surface | NIPPON PMC KK (JP) | 1996-12-04 | — | — | CN | disclosed |