Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16829403 | 0.87 | CTSS (0.44) | CTSSP2RX7HSD11B1ARNFE2L2 | |
| SCHEMBL6041965 | 0.83 | CA2 (0.41) | CTSSALDH1A1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL10451316 | 0.79 | AR (0.49) | CTSSARNFE2L2ALDH1A1KDM4E | |
| SCHEMBL22208564 | 0.79 | AR (0.44) | CTSSP2RX7HSD11B1ARNFE2L2 | |
| SCHEMBL31697313 | 0.79 | AR (0.44) | CTSSP2RX7HSD11B1ARNFE2L2 | |
| SCHEMBL23977880 | 0.79 | SCN8A (0.44) | CTSSP2RX7HSD11B1ARNFE2L2 | |
| SCHEMBL29749364 | 0.79 | AR (0.49) | CTSSARNFE2L2ALDH1A1KDM4E | |
| SCHEMBL27439941 | 0.79 | P2RX7 (0.46) | CTSSP2RX7ARSMN1; SMN2CYP1A2 | |
| SCHEMBL2783256 | 0.78 | ULK1 (0.40) | CTSSP2RX7HSD11B1ARNFE2L2 | |
| SCHEMBL9820988 | 0.78 | CA2 (0.47) | CTSSARALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |