SCHEMBL212131

SCHEMBL212131

Nc1nc2ccccc2c2[nH]cnc12

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 4/20 0.44
TLR8 Q9NR97 3/20 0.44
ADORA3 P0DMS8 2/20 0.43
ADORA2A P29274 2/20 0.43
ADORA1 P30542 1/20 0.43
DCPS Q96C86 1/20 0.43
ALDH1A1 P00352 4/20 0.42
HPGD P15428 4/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
KDM4E B2RXH2 3/20 0.42
HSD17B10 Q99714 3/20 0.42
ADRA1A P35348 2/20 0.42
KCNH2 Q12809 2/20 0.42
GLA P06280 2/20 0.42
CASP1 P29466 2/20 0.42
CASP7 P55210 2/20 0.42
CHRM2 P08172 1/20 0.42
ADRA2A P08913 1/20 0.42
CHRM1 P11229 1/20 0.42
NQO2 P16083 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29694218 1.00 TLR7 (0.44) TLR7TLR8ADORA3ADORA2AADORA1
Hydrochloric Acid SCHEMBL5523405 0.98 RAB9A (0.44) TLR7TLR8ADORA3ADORA2AADORA1
Hydrochloric Acid SCHEMBL10587438 0.97 ALDH1A1 (0.46) TLR7TLR8ADORA3ADORA2AADORA1
SCHEMBL28312743 0.95 TLR7 (0.44) TLR7TLR8ADORA3ADORA2AADORA1
Isobutanol SCHEMBL9386343 0.87 TLR7 (0.47) TLR7TLR8ADORA2AADRA1AKCNH2
Trifluoroacetic Acid SCHEMBL4984421 0.87 TLR7 (0.40) TLR7TLR8ADORA3ADORA2AADORA1
Trifluoroacetic Acid SCHEMBL7096569 0.87 TLR7 (0.40) TLR7TLR8ADORA3ADORA2AADORA1
SCHEMBL14127897 0.85 ADORA3 (0.36) TLR7TLR8ADORA3ADORA2AADORA1
SCHEMBL14127899 0.82 SMN1; SMN2 (0.39) TLR7TLR8ADORA3ADORA2AADORA1
SCHEMBL6099467 0.82 MAPT (0.42) TLR7ADORA3ALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1358 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240368155-A1 ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF DYNAVAX TECHNOLOGIES CORPORATION (US) 2024-11-07 US claimed
EP-3887369-B1 N-1 BRANCHED ALKYL ETHER SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) 2024-05-08 EP claimed
EP-3615539-B1 2-AMINO-QUINOLINE DERIVATIVES BIRDIE BIOPHARMACEUTICALS INC (KY) 2023-08-09 EP claimed
CN-114716555-A Compounds and compositions for targeting EGFR expressing tumors 博笛生物科技有限公司 2022-07-08 CN claimed
CN-114671954-A Compounds and compositions targeting HER2 positive tumors 博笛生物科技有限公司 2022-06-28 CN claimed
EP-3849615-A1 COMPOSITIONS FOR THE TREATMENT OF DISEASE WITH IMMUNE STIMULATORY CONJUGATES Silverback Therapeutics, Inc. (US) 2021-07-21 EP claimed
WO-2020056008-A1 COMPOSITIONS FOR THE TREATMENT OF DISEASE WITH IMMUNE STIMULATORY CONJUGATES SILVERBACK THERAPEUTICS, INC. (US) 2020-03-19 WO claimed
EP-3344262-A1 IMMUNE CELLS HAVING INCREASED IMMUNITY OR RESISTANCE TO AN IMMUNOSUPPRESSIVE CYTOKINE AND USE OF THE SAME Innate Tumor Immunity, Inc. (US) 2018-07-11 EP claimed
US-20170266297-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZOQUINOLIN(AMINES) AND DERIVATIVES THEREOF SUITABLE FOR LOCAL ADMINISTRATION TELORMEDIX SA (CH) 2017-09-21 US claimed
EP-3176169-A1 POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION RATES Yu, Chongxi (US) 2017-06-07 EP claimed
EP-0636031-A1 VACCINE ADJUVANT. MINNESOTA MINING & MFG (US) 1995-02-01 EP claimed
WO-1995002598-A1 FUSED CYCLOALKYLIMIDAZOPYRIDINES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-01-26 WO claimed
WO-1994017043-A1 PROCESS FOR PREPARING QUINOLINE AMINES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-08-04 WO claimed
EP-0575549-A1 PROCESS FOR IMIDAZO 4,5-c]QUINOLIN-4-AMINES. MINNESOTA MINING & MFG (US) 1993-12-29 EP claimed
WO-1993020847-A1 VACCINE ADJUVANT MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-10-28 WO claimed
US-5175296-A Reacting 1H-imidazolo(4,5-c)quinolin-5N-oxide with organic isocyanate; hydrolysis MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-12-29 US claimed
WO-1992015581-A1 PROCESS FOR IMIDAZO[4,5-c]QUINOLIN-4-AMINES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-09-17 WO claimed
EP-0385630-A2 1H-imidazo(4,5-c)Quinolin-4-amines as antivirals RIKER LABORATORIES, INC. (US) 1990-09-05 EP claimed
EP-0145340-B1 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines RIKER LABORATORIES, INC. (US) 1990-01-24 EP claimed
EP-0145340-A2 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines RIKER LABORATORIES, INC. (US) 1985-06-19 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170266297-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZOQUINOLIN(AMINES) AND DERIVATIVES THEREOF SUITABLE FOR LOCAL ADMINISTRATION IDO2, IDO1, TLR5 TLR7 6/4885TLR8 27/4885ADORA3 84/4885
US-20240368155-A1 ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885ADORA3 214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.