Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094099 | 0.89 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL21217528 | 0.88 | ROCK1 (0.37) | ROCK2ROCK1 | |
| SCHEMBL21217863 | 0.87 | ROCK1 (0.40) | ROCK2ROCK1 | |
| SCHEMBL21217850 | 0.85 | ROCK2 (0.38) | ROCK2ROCK1 | |
| SCHEMBL21217527 | 0.85 | MKNK1 (0.40) | MKNK1ROCK2ROCK1 | |
| SCHEMBL21217888 | 0.84 | ROCK2 (0.44) | MKNK1ROCK2TRPV1ROCK1 | |
| SCHEMBL24094323 | 0.84 | ROCK2 (0.48) | ROCK2ROCK1 | |
| SCHEMBL24094335 | 0.83 | ROCK2 (0.38) | MKNK1ROCK2ROCK1 | |
| SCHEMBL21217824 | 0.83 | ROCK2 (0.44) | MKNK1ROCK2ROCK1 | |
| SCHEMBL21217774 | 0.83 | CACNA2D1 (0.37) | MKNK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019145729-A9 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019145729-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2019-08-01 | — | — | WO | disclosed |