Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21218475 | 0.84 | IKBKB (0.39) | IKBKBCHUKBRD4MAPK1SMN1; SMN2 | |
| SCHEMBL21218410 | 0.80 | DYRK1A (0.36) | L3MBTL1ACLYIDO1ADORA2AADORA1 | |
| SCHEMBL21218367 | 0.76 | ACLY (0.61) | IKBKBCHUKBRD4ACLY | |
| SCHEMBL21218359 | 0.72 | BRD4 (0.39) | IKBKBCHUKBRD4MAPK1SMN1; SMN2 | |
| SCHEMBL28783302 | 0.68 | IKBKB (0.51) | IKBKBCHUKACLYAXLCDK8 | |
| SCHEMBL21218164 | 0.67 | DYRK1A (0.47) | MAPK1SMN1; SMN2HSD17B10L3MBTL1IDO1 | |
| SCHEMBL21920740 | 0.67 | IMPDH2 (0.44) | IKBKBCHUKRIPK1BRD4IMPDH2 | |
| SCHEMBL21218363 | 0.65 | CRBN (0.50) | IDO1 | |
| SCHEMBL25924559 | 0.64 | CRBN (0.60) | — | |
| SCHEMBL4685194 | 0.64 | IKBKB (1.00) | IKBKBCHUKBRD4CDK8XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019147783-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-01 | — | — | WO | disclosed |