Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ATIC | P31939 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30088006 | 0.78 | XDH (0.46) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL21920738 | 0.78 | NR3C1 (0.56) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL28601707 | 0.78 | XDH (0.46) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL3707241 | 0.75 | IMPDH2 (0.50) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL30087939 | 0.72 | XDH (0.44) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL28604961 | 0.72 | XDH (0.44) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL21921435 | 0.72 | XDH (0.39) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL16636645 | 0.71 | IMPDH2 (0.50) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL8530077 | 0.71 | IMPDH2 (0.50) | IMPDH2IMPDH1RIPK1XDHSLC22A12 | |
| SCHEMBL988243 | 0.71 | IMPDH2 (0.50) | IMPDH2IMPDH1RIPK1XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |