Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22620625 | 0.82 | MAPT (0.44) | MAPTPOLBCES2CES1AKT1 | |
| SCHEMBL22036325 | 0.81 | LMNA (0.36) | MAPTPOLBCES2CES1AKT1 | |
| SCHEMBL22071895 | 0.81 | LMNA (0.36) | MAPTPOLBCES2CES1AKT1 | |
| SCHEMBL24884816 | 0.78 | AKT1 (0.35) | MAPTCES2CES1AKT1ALDH1A1 | |
| SCHEMBL10304521 | 0.77 | NFE2L2 (0.64) | MAPTPOLBCES2CES1AKT1 | |
| SCHEMBL668443 | 0.77 | NFE2L2 (0.64) | MAPTPOLBCES2CES1AKT1 | |
| SCHEMBL11498687 | 0.77 | NFE2L2 (0.64) | MAPTPOLBCES2CES1AKT1 | |
| SCHEMBL19300441 | 0.77 | AKT1 (0.38) | MAPTCES2CES1AKT1ALDH1A1 | |
| SCHEMBL20625867 | 0.77 | MEN1 (0.32) | AKT1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL20908860 | 0.76 | MEN1 (0.32) | AKT1MEN1KMT2ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019150119-A1 | 4-HYDROXYPIPERIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2019-08-08 | — | — | WO | disclosed |