Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 3/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15828042 | 0.68 | HSD11B1 (0.36) | NPC1RAB9AALDH1A1HPGDL3MBTL1 | |
| SCHEMBL22036678 | 0.64 | L3MBTL1 (0.31) | L3MBTL1 | |
| SCHEMBL677246 | 0.64 | ALDH1A1 (0.33) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL14164164 | 0.63 | CHRNB4 (0.38) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL17327925 | 0.61 | KDM4E (0.36) | NPC1RAB9AKDM4EMAPTLMNA | |
| SCHEMBL12599050 | 0.61 | ALDH1A1 (0.33) | NPC1RAB9AALDH1A1KMT2ANOTUM | |
| SCHEMBL462826 | 0.60 | L3MBTL1 (0.38) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL27971872 | 0.59 | ALDH1A1 (0.47) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| Biphenyl SCHEMBL10535512 | 0.56 | ALDH1A1 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL21151429 | 0.56 | SMN1; SMN2 (0.44) | NPC1RAB9AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |