Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861521 | 1.00 | HTR2C (0.47) | HTR2CHTR2BTSHRCTSCELANE | |
| SCHEMBL21241510 | 0.92 | LMNA (0.50) | HTR2CHTR2BTSHRFKBP1ANPC1 | |
| SCHEMBL22861524 | 0.92 | LMNA (0.50) | HTR2CHTR2BTSHRFKBP1ANPC1 | |
| SCHEMBL25756614 | 0.88 | FKBP1A (0.50) | FKBP1AALDH1A1SMN1; SMN2 | |
| SCHEMBL22861529 | 0.88 | FKBP1A (0.50) | FKBP1AALDH1A1SMN1; SMN2 | |
| SCHEMBL7222149 | 0.87 | FKBP1A (0.53) | FKBP1A | |
| SCHEMBL7287503 | 0.86 | HTR2C (0.46) | HTR2CHTR2BTSHRCTSCELANE | |
| SCHEMBL693351 | 0.85 | TSHR (0.63) | HTR2CHTR2BTSHRCTSCELANE | |
| SCHEMBL4069956 | 0.85 | TSHR (0.63) | HTR2CHTR2BTSHRCTSCELANE | |
| SCHEMBL630517 | 0.85 | TSHR (0.63) | HTR2CHTR2BTSHRCTSCELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746440-B1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | UNIV TEXAS (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2019152527-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-08-08 | — | — | WO | disclosed |