Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121819 | 0.83 | GRIN2D (0.41) | DPYDPKMGAAHSD17B10KDM4E | |
| SCHEMBL12946182 | 0.83 | HSD17B10 (0.50) | DPYDPKMGAAHSD17B10KDM4E | |
| SCHEMBL20599392 | 0.74 | PDE3A (0.50) | DPYDGAAHSD17B10KDM4EHPGD | |
| SCHEMBL7345760 | 0.74 | KDM4E (0.54) | DPYDGAAHSD17B10KDM4EHPGD | |
| SCHEMBL21736999 | 0.67 | — | — | |
| SCHEMBL14857846 | 0.65 | ALOX15 (0.52) | GAAHSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL5861892 | 0.65 | — | — | |
| SCHEMBL19384952 | 0.65 | — | — | |
| SCHEMBL13093764 | 0.65 | GRIN2D (0.45) | GAAHSD17B10KDM4EHPGDGRIN2D | |
| SCHEMBL21242333 | 0.65 | HSD17B10 (0.34) | DPYDPKMGAAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030145-B2 | Pyridinyl derivatives for the treatment of depression | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| US-20040209917-A1 | Pyridinyl derivatives for the treatment of depression | HARTZ RICHARD A (US) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209917-A1 | Pyridinyl derivatives for the treatment of depression | CRH, CRHR1, CRHR2 | DPYD 2877/4885PKM 796/4885GAA 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.