Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246427 | 0.90 | SLC1A2 (0.47) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL21246424 | 0.89 | P2RX7 (0.40) | — | |
| SCHEMBL21246362 | 0.88 | LMNA (0.46) | GAAALDH1A1ANPEPMAPK1L3MBTL1 | |
| SCHEMBL21246428 | 0.88 | LMNA (0.48) | GAAALDH1A1ANPEPMEN1KMT2A | |
| SCHEMBL21246359 | 0.84 | SLC1A2 (0.51) | GAAHPGDKMT2AMAPTRAB9A | |
| SCHEMBL21246341 | 0.84 | LMNA (0.48) | GAAHPGDALDH1A1MAPK1TSHR | |
| SCHEMBL21246337 | 0.83 | HSD11B1 (0.41) | GAAHSD11B1MAPTPOLBRAB9A | |
| SCHEMBL21246364 | 0.82 | CYP3A4 (0.41) | — | |
| SCHEMBL21246349 | 0.81 | USP19 (0.33) | — | |
| SCHEMBL21246360 | 0.80 | USP19 (0.32) | HSD11B1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152688-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |