Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL21246922 | 0.96 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL28860899 | 0.96 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL9575581 | 0.88 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL28695468 | 0.88 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL30614197 | 0.88 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL10483809 | 0.88 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL5804636 | 0.88 | — | — | |
| Urea SCHEMBL8523142 | 0.88 | — | — | |
| Urea SCHEMBL15517775 | 0.88 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 | |
| Urea SCHEMBL9239354 | 0.88 | LMNA (0.50) | LMNAALDH1A1OR51E2TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019153624-A1 | GAS GENERATING AGENT COMPOSITION FOR REDUCING COMBUSTION TEMPERATURE AND MAINTAINING MORPHOLOGY, PREPARATION METHOD THEREFOR, APPLICATION THEREOF AND GAS GENERATOR | 湖北航鹏化学动力科技有限责任公司 | 2019-08-15 | — | — | WO | disclosed |