Urea

Urea

SCHEMBL9575581

NC(N)=O.O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Ca+2]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.50
ALDH1A1 P00352 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
OR51E2 Q9H255 1/20 0.50
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
CA5A P35218 1/20 0.43
CA5B Q9Y2D0 1/20 0.43
TSHR P16473 2/20 0.36
CYP3A4 P08684 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ACHE P22303 1/20 0.36
BLM P54132 3/20 0.35
LDHA P00338 2/20 0.35
ALOX15 P16050 1/20 0.33
PMP22 Q01453 1/20 0.33
GAA P10253 1/20 0.32
HBB P68871 1/20 0.32
HIF1A Q16665 1/20 0.32
LDHB P07195 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL28350590 0.96 LMNA (0.46) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL28216962 0.96 LMNA (0.46) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL28350165 0.96 LMNA (0.46) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL28353975 0.93 LMNA (0.43) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL5804636 0.92
Urea SCHEMBL15517775 0.92 LMNA (0.50) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL30614197 0.92 LMNA (0.50) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL8523142 0.92
Urea SCHEMBL10483809 0.92 LMNA (0.50) LMNAALDH1A1TDP1OR51E2MEN1
Urea SCHEMBL21246922 0.92 LMNA (0.50) LMNAALDH1A1TDP1OR51E2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790852-B1 IMPROVED UREA-BASED BLEND COMPOSITION AND METHOD FOR THE MANUFACTURE THEREOF YARA INT ASA (NO) 2025-12-03 EP claimed
CN-108349827-B Improved urea-based blend composition and method of making same 雅苒国际集团 2024-09-06 CN claimed
EP-3592719-B1 UREA-BASED COMPOSITION AND METHOD FOR THE MANUFACTURE THEREOF YARA INT ASA (NO) 2024-08-07 EP claimed
EP-4058422-B1 UREA-BASED BLEND COMPOSITION AND METHOD FOR THE MANUFACTURE THEREOF YARA INT ASA (NO) 2024-03-27 EP claimed
CN-116425580-A Production device and production method of urea calcium nitrate fertilizer 河南心连心化学工业集团股份有限公司 2023-07-14 CN claimed
CN-219279769-U Apparatus for producing of urea calcium nitrate fertilizer 河南心连心化学工业集团股份有限公司 2023-06-30 CN claimed
EP-3941890-B1 THE USE OF AN OIL-BASED COMPOSITION FOR REDUCING AMMONIA VOLATILIZATION IN UREA-BASED FERTILIZER APPLICATION YARA UK LTD (GB) 2023-06-07 EP claimed
EP-3374332-B1 IMPROVED UREA-BASED BLEND COMPOSITION AND METHOD FOR THE MANUFACTURE THEREOF YARA INT ASA (NO) 2023-06-07 EP claimed
CN-113518768-B Use of oil-based compositions for reducing ammonia volatilization in urea-based fertilizer applications 雅拉英国有限公司 2023-05-16 CN claimed
US-11578009-B2 Urea-based blend composition and method for the manufacture thereof YARA INTERNATIONAL ASA (NO) 2023-02-14 US claimed
EP-3366659-A1 LIQUID UREASE INHIBITOR FORMULATIONS Yara International ASA (NO) 2018-08-29 EP claimed
EP-2890661-B1 METHOD FOR LIMITING THE USE OF AN AMMONIUM NITRATE FERTILIZER AS A PRECURSOR FOR AN EXPLOSIVE AND COMPOSITION THEREFOR YARA INT ASA (NO) 2018-04-04 EP claimed
WO-2017144698-A1 LIQUID UREASE INHIBITOR FORMULATIONS YARA INTERNATIONAL ASA (NO) 2017-08-31 WO claimed
EP-3210959-A1 LIQUID UREASE INHIBITOR FORMULATION, METHOD OF MANUFACTURING AND SOLID PARTICULATES COMPRISING IT YARA International ASA (NO) 2017-08-30 EP claimed
WO-2017081183-A1 IMPROVED UREA-BASED BLEND COMPOSITION AND METHOD FOR THE MANUFACTURE THEREOF YARA INTERNATIONAL ASA (NO) 2017-05-18 WO claimed
CN-103626435-B A kind of coal and rock inorganic filler enclosed material 山东优固新材料科技有限公司 2016-08-17 CN claimed
US-9328031-B2 Method for limiting the use of an ammonium nitrate fertilizer as a precursor for an explosive and composition therefor YARA INTERNATIONAL ASA (NO) 2016-05-03 US claimed
US-20150218058-A1 METHOD FOR LIMITING THE USE OF AN AMMONIUM NITRATE FERTILIZER AS A PRECURSOR FOR AN EXPLOSIVE AND COMPOSITION THEREFOR YARA INTERNATIONAL ASA (NO) 2015-08-06 US claimed
EP-2890661-A2 METHOD FOR LIMITING THE USE OF AN AMMONIUM NITRATE FERTILIZER AS A PRECURSOR FOR AN EXPLOSIVE AND COMPOSITION THEREFOR YARA International ASA (NO) 2015-07-08 EP claimed
WO-2014033161-A2 METHOD FOR LIMITING THE USE OF AN AMMONIUM NITRATE FERTILIZER AS A PRECURSOR FOR AN EXPLOSIVE AND COMPOSITION THEREFOR YARA INTERNATIONAL ASA (NO) 2014-03-06 WO claimed