Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21250438 | 0.96 | DRD2 (0.40) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23018414 | 0.93 | DRD2 (0.38) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21250446 | 0.92 | DRD2 (0.36) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21291460 | 0.92 | ROCK2 (0.43) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21250349 | 0.92 | DRD2 (0.35) | ROCK1ROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18667166 | 0.88 | DRD2 (0.36) | DRD2ABL1HDAC1HDAC3HDAC6 | |
| SCHEMBL21939747 | 0.87 | DRD2 (0.40) | ROCK1ROCK2CYP2C9DRD2KDR | |
| SCHEMBL21250362 | 0.86 | DRD2 (0.35) | DRD2ABL1HDAC1HDAC3HDAC6 | |
| SCHEMBL18667825 | 0.86 | HDAC1 (0.39) | ROCK1ROCK2DRD2KDRCHEK1 | |
| SCHEMBL21250324 | 0.86 | KDM1A (0.44) | ROCK1ROCK2DRD2ABL1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377748-B2 | Hepatitis B core protein modulators | ASSEMBLY BIOSCIENCES, INC. (US) | 2019-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377748-B2 | Hepatitis B core protein modulators | HAVCR2, FABP1, MAVS | ROCK1 4004/4885ROCK2 3353/4885CYP3A4 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.