Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331101 | 0.93 | MEN1 (0.36) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL21240537 | 0.88 | NOS1 (0.36) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL29578158 | 0.88 | NOS1 (0.36) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL30442682 | 0.88 | NOS1 (0.36) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL21251942 | 0.88 | TTK (0.37) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL20331789 | 0.86 | NOS1 (0.38) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL30045100 | 0.86 | NOS1 (0.38) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL20331796 | 0.85 | NOS1 (0.40) | MEN1KMT2ANOS1PDE4BPDE4A | |
| SCHEMBL20331785 | 0.82 | TTK (0.35) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL21252374 | 0.82 | PDE10A (0.35) | MEN1KMT2APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |