Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 5/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578676 | 0.89 | SUV39H2 (0.36) | TTKPDE5ASUV39H2NEK2PLK1 | |
| SCHEMBL21240427 | 0.89 | SUV39H2 (0.36) | TTKPDE5ASUV39H2NEK2PLK1 | |
| SCHEMBL20331101 | 0.81 | MEN1 (0.36) | MEN1KMT2ASUV39H2PDE4BPDE4A | |
| SCHEMBL20331783 | 0.80 | F10 (0.33) | SUV39H2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL21240243 | 0.80 | TTK (0.38) | TTKNEK2PLK1NEK1PDE4B | |
| SCHEMBL29578389 | 0.80 | TTK (0.38) | TTKNEK2PLK1NEK1PDE4B | |
| SCHEMBL24488213 | 0.79 | GAK (0.33) | MEN1KMT2ATTKNEK2PLK1 | |
| SCHEMBL21251736 | 0.79 | TTK (0.35) | TTKNEK2PDE3BTP53 | |
| SCHEMBL20331789 | 0.78 | NOS1 (0.38) | MEN1KMT2ATTKPDE4BPDE4A | |
| SCHEMBL21240537 | 0.78 | NOS1 (0.36) | MEN1KMT2APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |