Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331101 | 0.86 | MEN1 (0.36) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL21251736 | 0.84 | TTK (0.35) | PDE3B | |
| SCHEMBL21252146 | 0.83 | TTK (0.37) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL20331980 | 0.82 | TTK (0.37) | — | |
| SCHEMBL21240427 | 0.82 | SUV39H2 (0.36) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL21240243 | 0.82 | TTK (0.38) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL29578389 | 0.82 | TTK (0.38) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL29578676 | 0.82 | SUV39H2 (0.36) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL20331785 | 0.81 | TTK (0.35) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL21252374 | 0.81 | PDE10A (0.35) | PDE4BPDE4APDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |