Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL54014 | 0.84 | SLC6A3 (0.46) | KMT2AMEN1SLC6A3POLBNPC1 | |
| SCHEMBL10918428 | 0.73 | SLC6A3 (0.50) | KMT2AMEN1SLC6A3MAPTALDH1A1 | |
| SCHEMBL10391386 | 0.73 | SLC6A3 (0.49) | KMT2AMEN1SLC6A3ALDH1A1CYP3A4 | |
| SCHEMBL10827630 | 0.72 | MEN1 (0.45) | KMT2AMEN1SLC6A3ALDH1A1PTGER4 | |
| SCHEMBL11767308 | 0.72 | ELANE (0.52) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL7860591 | 0.71 | MEN1 (0.45) | KMT2AMEN1SLC6A3TNK2NPC1 | |
| SCHEMBL10827795 | 0.70 | MEN1 (0.43) | KMT2AMEN1SLC6A3MAPTALDH1A1 | |
| SCHEMBL5071034 | 0.70 | LMNA (0.51) | KMT2AMEN1SLC6A3RAB9AMAPT | |
| SCHEMBL1743566 | 0.69 | SLC6A3 (0.61) | KMT2ASLC6A3ALDH1A1HPGD | |
| SCHEMBL14233517 | 0.69 | SLC6A3 (0.61) | KMT2ASLC6A3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2442807-A1 | TREATMENT OF HOT FLUSHES, VASOMOTOR SYMPTOMS, AND NIGHT SWEATS WITH SEX STEROID PRECURSORS IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | Endorecherche, Inc. (CA) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145010-A1 | TREATMENT OF HOT FLUSHES, VASOMOTOR SYMPTOMS, AND NIGHT SWEATS WITH SEX STEROID PRECURSORS IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | ENDORECHERCHE, INC. (CA) | 2010-12-23 | — | — | WO | disclosed |