SCHEMBL1743566

SCHEMBL1743566

COC(=O)C(OC1CCCCO1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 12/20 0.61
SLC6A2 P23975 2/20 0.45
SLC6A4 P31645 1/20 0.45
DHFR P00374 1/20 0.45
TDP1 Q9NUW8 2/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
TSHR P16473 1/20 0.44
GAA P10253 1/20 0.43
HPGD P15428 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14211627 1.00 SLC6A3 (0.61) SLC6A3SLC6A2SLC6A4DHFRTDP1
SCHEMBL14233517 1.00 SLC6A3 (0.61) SLC6A3SLC6A2SLC6A4DHFRTDP1
SCHEMBL5570406 0.87 SLC6A3 (0.49) SLC6A3SLC6A2SLC6A4TDP1ALDH1A1
SCHEMBL14438434 0.87 SLC6A3 (0.49) SLC6A3SLC6A2SLC6A4TDP1ALDH1A1
SCHEMBL10391386 0.86 SLC6A3 (0.49) SLC6A3TDP1ALDH1A1LMNATSHR
SCHEMBL8637525 0.86 SLC6A3 (0.60) SLC6A3SLC6A2SLC6A4DHFRTDP1
SCHEMBL10918428 0.84 SLC6A3 (0.50) SLC6A3TDP1ALDH1A1LMNATSHR
SCHEMBL54014 0.83 SLC6A3 (0.46) SLC6A3TDP1ALDH1A1LMNATSHR
SCHEMBL8637626 0.81 TSHR (0.60) SLC6A3TDP1ALDH1A1LMNATSHR
SCHEMBL23349257 0.80 SLC6A3 (0.51) SLC6A3SLC6A2SLC6A4DHFRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121421-B1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS AG (CH) 2026-03-11 EP disclosed
US-20240382600-A1 BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER NOVARTIS AG (CH) 2024-11-21 US disclosed
US-20240382457-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS PHARMA AG (CH) 2024-11-21 US disclosed
US-12083101-B2 Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors NOVARTIS AG (CH) 2024-09-10 US disclosed
EP-4395828-A1 BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER Novartis AG (CH) 2024-07-10 EP disclosed
WO-2023031801-A1 BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER NOVARTIS AG (CH) 2023-03-09 WO disclosed
EP-4121421-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS Novartis AG (CH) 2023-01-25 EP disclosed
US-20210299100-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS PHARMA AG (CH) 2021-09-30 US disclosed
US-20210299100-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS PHARMA AG (CH) 2021-09-30 US disclosed
WO-2021186324-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS AG (CH) 2021-09-23 WO disclosed
WO-2021186324-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS AG (CH) 2021-09-23 WO disclosed
EP-2387574-A1 OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS Merck Sharp & Dohme Corp. (US) 2011-11-23 EP disclosed
US-20110253463-A1 MODULAR HYBRID ELECTRIC VEHICLE SYSTEM SMITH MARK ERIC 2011-10-20 US disclosed
US-20100184799-A1 OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS MERCK SHARP & DOHME CORP. 2010-07-22 US disclosed
WO-2010083136-A1 OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2010-07-22 WO disclosed
EP-1538148-B1 CHIRAL SENSOR JAPAN SCIENCE & TECH AGENCY (JP) 2007-01-10 EP disclosed
EP-0323864-A2 Lipophilic oxadiazoles MERCK SHARP & DOHME LTD. (GB) 1989-07-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240382600-A1 BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER YAP1, JMJD7, TOR1AIP1 SLC6A3 3165/4885SLC6A2 2652/4885SLC6A4 3589/4885
US-12083101-B2 Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors YAP1, TEAD3, TEAD2 SLC6A3 3806/4885SLC6A2 3628/4885SLC6A4 4459/4885
US-20100184799-A1 OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS GPR119, SSTR3, SSTR2 SLC6A3 283/4885SLC6A2 404/4885SLC6A4 308/4885
US-20240382457-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS YAP1, TEAD3, TEAD2 SLC6A3 3806/4885SLC6A2 3628/4885SLC6A4 4459/4885
US-20210299100-A1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS YAP1, TEAD3, TEAD2 SLC6A3 3875/4885SLC6A2 3704/4885SLC6A4 4472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.