SCHEMBL21257960

SCHEMBL21257960

O=C(N1CC2CN(Cc3ccc(F)cc3)CC2C1)n1cc(C(F)(F)F)cn1

nearest known ligand 0.67

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21257988 0.90 FAAH (0.50) FAAH
SCHEMBL21257965 0.87 FAAH (0.48) FAAH
SCHEMBL21258000 0.87 FAAH (0.48) FAAH
SCHEMBL21276224 0.86 FAAH (0.55) FAAH
SCHEMBL21276338 0.85 FAAH (0.52) FAAH
SCHEMBL20558170 0.84 FAAH (0.56) FAAH
SCHEMBL21276292 0.84 FAAH (0.53) FAAH
SCHEMBL21276189 0.83 FAAH (0.48) FAAH
SCHEMBL21257987 0.83 FAAH (0.43) FAAH
SCHEMBL21257975 0.82 FAAH (0.48) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10385057-B2 Pyrazole compounds and methods of making and using same LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2019-08-20 US disclosed
US-10385057-B2 Pyrazole compounds and methods of making and using same LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2019-08-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10385057-B2 Pyrazole compounds and methods of making and using same FAAH, FAAH2, MGLL FAAH 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.