Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | SORD | Q00796 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615343 | 0.83 | KDM4E (0.60) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30643023 | 0.83 | KDM4E (0.60) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL12813743 | 0.77 | KDM4E (0.53) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21258881 | 0.75 | VNN1 (0.33) | PTPN11SORDLRRK2 | |
| SCHEMBL21259003 | 0.74 | PTPN11 (0.36) | PTPN11SORDLRRK2 | |
| SCHEMBL21258931 | 0.74 | PTPN11 (0.33) | HTR2CPTPN11SORDLRRK2 | |
| SCHEMBL12813911 | 0.74 | HTR2A (0.57) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7385367 | 0.74 | KDM4E (0.57) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL939716 | 0.73 | ALDH1A1 (0.70) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21258878 | 0.73 | KDM4E (0.38) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210338665-A1 | MEDICAL USE OF PROSTACYCLIN RECEPTOR AGONIST | CHINESE PLA GENERAL HOSPITAL (CN) | 2021-11-04 | — | — | US | disclosed |
| US-20210087168-A1 | PROSTACYCLIN RECEPTOR AGONIST | MEDSHINE DISCOVERY INC. (CN) | 2021-03-25 | — | — | US | disclosed |
| WO-2021023271-A1 | CRYSTAL FORM OF COMPOUND AS PROSTACYCLIN RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR | 南京明德新药研发有限公司 | 2021-02-11 | — | — | WO | disclosed |
| EP-3750879-A1 | PROSTACYCLIN RECEPTOR AGONIST | Medshine Discovery Inc. (CN) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019154363-A1 | PROSTACYCLIN RECEPTOR AGONIST | 南京明德新药研发有限公司 | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087168-A1 | PROSTACYCLIN RECEPTOR AGONIST | PTGIR, TBXA2R, PTGFR | KDM4E 4782/4885MEN1 2717/4885ALDH1A1 987/4885 |
| US-20210338665-A1 | MEDICAL USE OF PROSTACYCLIN RECEPTOR AGONIST | PTGIR, CYP11B2, PDE8A | KDM4E 4473/4885MEN1 3411/4885ALDH1A1 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.