Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 19/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8696754 | 0.88 | KDM4E (0.46) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL8696748 | 0.88 | KDM4E (0.46) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30425445 | 0.82 | PTPN11 (0.50) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL31015127 | 0.81 | KDM4E (0.53) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL12615343 | 0.80 | KDM4E (0.60) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30643023 | 0.80 | KDM4E (0.60) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28996159 | 0.78 | KDM4E (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30252639 | 0.78 | KDM4E (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7391235 | 0.77 | HTR3E (0.61) | MEN1ALDH1A1CYP1A2KMT2APTPN11 | |
| SCHEMBL939716 | 0.77 | ALDH1A1 (0.70) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | claimed |
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| CN-1106400-A | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions in which they are present | SANOFI SA (FR) | 1995-08-09 | — | — | CN | disclosed |
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |