Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13890680 | 0.73 | — | — | |
| SCHEMBL23823337 | 0.70 | DHODH (0.41) | SMN1; SMN2ALDH1A1HPGDCASP1WDR5 | |
| SCHEMBL10126900 | 0.68 | TAS1R3 (0.54) | ALDH1A1HPGDGAAKMT2AKDM4E | |
| SCHEMBL24458105 | 0.68 | EZH2 (0.43) | SMN1; SMN2ALDH1A1CASP1WDR5GAA | |
| SCHEMBL21307918 | 0.68 | BRAF (0.43) | ALDH1A1HPGDGAAKMT2AKDM4E | |
| SCHEMBL14401952 | 0.67 | GPR27 (0.44) | SMN1; SMN2ALDH1A1HPGDCASP1GAA | |
| SCHEMBL12900908 | 0.65 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1HPGDGAARAB9A | |
| SCHEMBL7706279 | 0.65 | HPGD (0.59) | SMN1; SMN2ALDH1A1HPGDGAARAB9A | |
| SCHEMBL20900607 | 0.64 | GAA (0.50) | SMN1; SMN2ALDH1A1HPGDCASP1GAA | |
| SCHEMBL1005549 | 0.63 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1GAAKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019153080-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-08-15 | — | — | WO | disclosed |