Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 10/20 | 0.54 |
| ▸ | NT5E | P21589 | 2/20 | 0.54 |
| ▸ | ADH1A | P07327 | 1/20 | 0.48 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.48 |
| ▸ | FHIT | P49789 | 2/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 5/20 | 0.47 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21263989 | 0.89 | NT5E (0.54) | IMPDH2NT5ESRCP2RY2P2RY1 | |
| SCHEMBL21263919 | 0.83 | FHIT (0.41) | IMPDH2ADH1AP2RY11ENPP1FHIT | |
| SCHEMBL24258564 | 0.80 | IMPDH2 (0.46) | IMPDH2NT5EADH1AFHITIMPDH1 | |
| SCHEMBL21263869 | 0.77 | AHCY (0.43) | IMPDH2ADH1AFHITIMPDH1P2RY1 | |
| SCHEMBL24258562 | 0.75 | BCHE (0.42) | IMPDH2ADH1AFHITIMPDH1NADK | |
| SCHEMBL24254538 | 0.75 | NT5E (0.76) | IMPDH2NT5EP2RY11ENPP1FHIT | |
| SCHEMBL24254535 | 0.75 | NT5E (0.76) | IMPDH2NT5EP2RY11ENPP1FHIT | |
| SCHEMBL24659506 | 0.75 | NT5E (0.76) | IMPDH2NT5EP2RY11ENPP1FHIT | |
| SCHEMBL22399426 | 0.75 | NT5E (0.76) | IMPDH2NT5EP2RY11ENPP1FHIT | |
| SCHEMBL29441942 | 0.75 | NT5E (0.76) | IMPDH2NT5EP2RY11ENPP1FHIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339185-B2 | Cyclic dinucleotides as anticancer agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-05-24 | — | — | US | disclosed |
| EP-3752516-B1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2022-02-23 | — | — | EP | disclosed |
| US-10519187-B2 | Cyclic dinucleotides as anticancer agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-12-31 | — | — | US | disclosed |
| US-20190248828-A1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10519187-B2 | Cyclic dinucleotides as anticancer agents | DPYD, NTPCR, CD38 | IMPDH2 84/4885NT5E 102/4885ADH1A 3178/4885 |
| US-11339185-B2 | Cyclic dinucleotides as anticancer agents | DPYD, NTPCR, CD38 | IMPDH2 84/4885NT5E 102/4885ADH1A 3178/4885 |
| US-20190248828-A1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | DPYD, NTPCR, CD38 | IMPDH2 84/4885NT5E 102/4885ADH1A 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.