Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21271972 | 0.80 | MAPT (0.36) | MAPTALDH1A1SMN1; SMN2PKMMAPK1 | |
| SCHEMBL27229486 | 0.78 | HTT (0.37) | SMN1; SMN2HTT | |
| SCHEMBL30977710 | 0.78 | HTT (0.37) | SMN1; SMN2HTT | |
| SCHEMBL31543922 | 0.77 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2CYP2C9CYP3A4 | |
| SCHEMBL21271947 | 0.76 | ALDH1A1 (0.38) | MAPTALDH1A1SMN1; SMN2PKMMEN1 | |
| SCHEMBL21272026 | 0.75 | MAPT (0.32) | MAPTALDH1A1SMN1; SMN2PKM | |
| SCHEMBL30847902 | 0.75 | F2RL1 (0.40) | MAPTALDH1A1SMN1; SMN2PKMMEN1 | |
| SCHEMBL27152331 | 0.75 | F2RL1 (0.40) | MAPTALDH1A1SMN1; SMN2PKMMEN1 | |
| SCHEMBL21271989 | 0.74 | MAPT (0.35) | MAPTALDH1A1SMN1; SMN2MAPK1CYP2C9 | |
| SCHEMBL21271988 | 0.74 | MAPT (0.35) | MAPTALDH1A1SMN1; SMN2MAPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492354-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2022-11-08 | — | — | US | disclosed |
| US-20210002288-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-01-07 | — | — | US | disclosed |
| US-20210002288-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-01-07 | — | — | US | disclosed |
| US-10752635-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-25 | — | — | US | disclosed |
| US-10752635-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-25 | — | — | US | disclosed |
| WO-2019164847-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION (US) | 2019-08-29 | — | — | WO | disclosed |
| US-20190256520-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
| US-20190256520-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002288-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | PDXK, PPIP5K2, PCK1 | MAPT 3880/4885ALDH1A1 2472/4885SMN1; SMN2 4471/4885 |
| US-10752635-B2 | Indazole compounds and uses thereof | PDXK, PPIP5K2, PCK1 | MAPT 3880/4885ALDH1A1 2472/4885SMN1; SMN2 4471/4885 |
| US-20190256520-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | PDXK, PPIP5K2, PCK1 | MAPT 3880/4885ALDH1A1 2472/4885SMN1; SMN2 4471/4885 |
| US-11492354-B2 | Indazole compounds and uses thereof | PDXK, PPIP5K2, PCK1 | MAPT 3880/4885ALDH1A1 2472/4885SMN1; SMN2 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.