Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25261179 | 0.91 | TEAD1 (0.52) | TEAD1TACR1MAPTRORCBCHE | |
| SCHEMBL21276388 | 0.87 | NR1H2 (0.50) | NR1H2JAK1JAK2MEN1CYP2C19 | |
| SCHEMBL4875893 | 0.86 | JAK1 (0.54) | NR1H2TACR1JAK1JAK2RORC | |
| SCHEMBL10320157 | 0.86 | JAK1 (0.54) | NR1H2TACR1JAK1JAK2RORC | |
| SCHEMBL10449417 | 0.86 | JAK1 (0.54) | NR1H2TACR1JAK1JAK2RORC | |
| SCHEMBL22435955 | 0.86 | JAK1 (0.54) | NR1H2TACR1JAK1JAK2RORC | |
| SCHEMBL29716428 | 0.83 | NR1H2 (0.56) | TEAD1NR1H2TACR1MAPTJAK1 | |
| SCHEMBL25326804 | 0.81 | PHGDH (0.49) | NR1H2TACR1MAPTRORCLIPE | |
| SCHEMBL3457225 | 0.81 | TEAD1 (0.61) | TEAD1MAPTBCHEACHEBACE1 | |
| SCHEMBL29588708 | 0.81 | TEAD1 (0.47) | TEAD1TACR1MAPTRORCBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2019-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | FAAH, FAAH2, MGLL | TEAD1 4229/4885NR1H2 377/4885TACR1 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.