Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 4/20 | 0.44 |
| ▸ | TACR1 | P25103 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17606049 | 0.89 | DNMT3A (0.45) | RORCSMN1; SMN2GPR119MEN1CYP2C19 | |
| SCHEMBL29589624 | 0.86 | KEAP1 (0.46) | RORCACHEGPR119ENPP2ATXN2 | |
| SCHEMBL25261179 | 0.85 | TEAD1 (0.52) | TEAD1MAPTRORCTACR1BCHE | |
| SCHEMBL25219110 | 0.83 | MAPT (0.56) | MAPTRORCTACR1GPR119TGFBR1 | |
| SCHEMBL29589334 | 0.83 | CA1 (0.44) | GPR119MEN1KMT2A | |
| SCHEMBL21276381 | 0.81 | TEAD1 (0.48) | TEAD1MAPTRORCTACR1BCHE | |
| SCHEMBL3457225 | 0.80 | TEAD1 (0.61) | TEAD1MAPTBCHEACHEBACE1 | |
| SCHEMBL31293700 | 0.78 | EHMT2 (0.40) | MAPTRORCSMN1; SMN2HTTEHMT2 | |
| SCHEMBL18357554 | 0.77 | ABHD6 (0.53) | TEAD1MAPTRORCGPR119 | |
| SCHEMBL16464443 | 0.77 | EHMT2 (0.39) | MAPTRORCSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848091-A | Inhibitors of ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP 1) and uses thereof | 1CBIO公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022091048-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2022-05-05 | — | — | WO | disclosed |