Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.51 |
| ▸ | CASP5 | P51878 | 3/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CASP4 | P49662 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21274287 | 0.87 | KCNH2 (0.45) | DRD4SIGMAR1HTR7ALDH1A1MAPT | |
| SCHEMBL21274094 | 0.85 | PARP1 (0.50) | HTR7 | |
| SCHEMBL21281583 | 0.84 | PARP1 (0.51) | HRH3HTR7 | |
| SCHEMBL21273960 | 0.83 | HRH3 (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21274069 | 0.83 | PARP1 (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21273939 | 0.82 | SLC6A2 (0.47) | DRD4HTR7 | |
| SCHEMBL21281512 | 0.81 | SIGMAR1 (0.42) | HRH3SIGMAR1 | |
| SCHEMBL21281500 | 0.81 | ADRA1A (0.45) | HTR7 | |
| SCHEMBL21274498 | 0.80 | HTR7 (0.43) | HRH3NPC1RAB9ADRD4SIGMAR1 | |
| SCHEMBL21268791 | 0.79 | HTR3E (0.43) | CASP1CASP5HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527209-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB Biopharma SPRL (BE) | 2019-08-21 | — | — | EP | disclosed |