SCHEMBL21282230

SCHEMBL21282230

Cc1ccc(C(c2ccc(CCc3cc(C)c(C)cc3C)c(C)c2)(C(F)(F)F)C(F)(F)F)cc1C

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ DAO P14920 1/20 0.40
▸ ESR1 P03372 1/20 0.33
▸ ESR2 Q92731 1/20 0.33
▸ RXRA P19793 1/20 0.33
▸ RXRB P28702 1/20 0.33
▸ RXRG P48443 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.31
▸ TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19465208 0.93 DAO (0.35) DAOESR1ESR2RXRARXRB
SCHEMBL15747030 0.83 DAO (0.36) DAOESR1ESR2RXRARXRB
SCHEMBL27437849 0.82 SMN1; SMN2 (0.46) DAORXRARXRBRXRGNPSR1
SCHEMBL21712680 0.82 LMNA (0.39) DAO
SCHEMBL47866 0.82 ESR1 (0.46) ESR1ESR2
SCHEMBL29728144 0.82 ESR1 (0.46) ESR1ESR2
SCHEMBL21514087 0.80 PPARG (0.37) DAOESR1
SCHEMBL13538944 0.80 ESR1 (0.50) ESR1ESR2
SCHEMBL22000812 0.80 TAAR1 (0.31) DAOESR1ESR2TAAR1
SCHEMBL15746150 0.76 KIF11 (0.42) DAOESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10471397-B2 High performance facilitated transport membranes for olefin/paraffin separations UOP LLC (US) 2019-11-12 — — US disclosed
US-20190255490-A1 HIGH PERFORMANCE FACILITATED TRANSPORT MEMBRANES FOR OLEFIN/PARAFFIN SEPARATIONS UOP LLC (US) 2019-08-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190255490-A1 HIGH PERFORMANCE FACILITATED TRANSPORT MEMBRANES FOR OLEFIN/PARAFFIN SEPARATIONS SLC43A1, SLC7A1, SLCO4C1 DAO 3249/4885ESR1 815/4885ESR2 1561/4885
US-10471397-B2 High performance facilitated transport membranes for olefin/paraffin separations SLC43A1, SLC7A1, SLCO4C1 DAO 3249/4885ESR1 815/4885ESR2 1561/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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