Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21283009 | 0.90 | GHSR (0.39) | KDM4EALDH1A1LMNANFKB1NFKB2 | |
| SCHEMBL18868656 | 0.77 | KMT2A (0.43) | KDM4EALDH1A1LMNANFKB1NFKB2 | |
| SCHEMBL20748226 | 0.77 | PPARG (0.38) | KDM4EALDH1A1LMNAPPARGCYP3A4 | |
| SCHEMBL22002383 | 0.75 | MAPT (0.41) | KDM4EALDH1A1LMNACYP3A4CYP2C9 | |
| SCHEMBL22002372 | 0.75 | MAPT (0.41) | KDM4EALDH1A1LMNACYP3A4CYP2C9 | |
| SCHEMBL18868661 | 0.74 | LMNA (0.43) | KDM4EALDH1A1LMNANFKB1NFKB2 | |
| SCHEMBL17826457 | 0.74 | MAPT (0.38) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25778077 | 0.74 | CA1 (0.40) | KDM4ECYP2C19 | |
| SCHEMBL17752495 | 0.73 | CETP (0.39) | — | |
| SCHEMBL17752491 | 0.73 | CETP (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723750-B2 | Sphingamide compounds and methods for binding iNKT cells | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190256541-A1 | SPHINGAMIDE COMPOUNDS AND METHODS FOR BINDING iNKT CELLS | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723750-B2 | Sphingamide compounds and methods for binding iNKT cells | UGCG, CD4, CERT1 | KDM4E 1354/4885ALDH1A1 4566/4885LMNA 1224/4885 |
| US-20190256541-A1 | SPHINGAMIDE COMPOUNDS AND METHODS FOR BINDING iNKT CELLS | UGCG, CD4, CERT1 | KDM4E 1354/4885ALDH1A1 4566/4885LMNA 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.