Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 11/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 11/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10426599 | 0.85 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL11361471 | 0.85 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3SIGMAR1 | |
| SCHEMBL23653978 | 0.79 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL234628 | 0.79 | SIGMAR1 (0.33) | SIGMAR1PLA2G1BPLA2G2A | |
| SCHEMBL27720579 | 0.76 | SIGMAR1 (0.34) | SIGMAR1PLA2G1BPLA2G2A | |
| SCHEMBL10793082 | 0.75 | — | — | |
| SCHEMBL175509 | 0.75 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL20860599 | 0.75 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL436979 | 0.75 | PLA2G1B (0.39) | SIGMAR1PLA2G1BPLA2G2A | |
| SCHEMBL23425906 | 0.73 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019161224-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | GiraFpharma LLC (US) | 2019-08-22 | — | — | WO | disclosed |