SCHEMBL21284198

SCHEMBL21284198

Nc1ncnc2c1ncn2[C@H]1C[C@H](OP(=O)(O)OC[C@@H]2CC[C@H](n3ccc(=O)[nH]c3=O)O2)[C@@H](COP(=O)(O)S)O1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ RNASEL Q05823 4/20 0.56
▸ DTYMK P23919 4/20 0.47
▸ P2RY2 P41231 2/20 0.47
▸ P2RY4 P51582 1/20 0.47
▸ P2RY6 Q15077 1/20 0.47
▸ POLB P06746 1/20 0.46
▸ TERT O14746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22352121 0.86 POLB (0.54) P2RY2POLB
SCHEMBL20763160 0.86 POLB (0.54) P2RY2POLB
SCHEMBL25582525 0.86 RNASEL (0.57) RNASELP2RY2POLB
SCHEMBL22340220 0.85 DTYMK (0.44) RNASELDTYMKPOLBTERT
SCHEMBL24239532 0.84 DTYMK (0.58) DTYMKPOLBTERT
SCHEMBL18158882 0.84 DTYMK (0.58) DTYMKPOLBTERT
SCHEMBL18158887 0.84 DTYMK (0.58) DTYMKPOLBTERT
SCHEMBL5852678 0.84 DTYMK (0.63) RNASELDTYMKTERT
SCHEMBL24325561 0.84 POLB (0.53) RNASELPOLB
SCHEMBL17948732 0.84 RNASEL (0.49) RNASELPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11744845-B2 Compounds,compositions, and methods for the treatment of disease F-star Therapeutics, Inc. (GB) 2023-09-05 — — US disclosed
WO-2019161171-A1 NANOPARTICLE FORMULATIONS OF STING AGONISTS SPEROVIE BIOSCIENCES, INC. (US) 2019-08-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11744845-B2 Compounds,compositions, and methods for the treatment of disease STING1, MAVS, IRF3 RNASEL 1374/4885DTYMK 1603/4885P2RY2 1016/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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