Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10396004 | 0.80 | CYP3A4 (0.59) | HPGDL3MBTL1MAPTNOS1NOS3 | |
| SCHEMBL5888020 | 0.80 | CXCL12 (0.40) | HSD17B10CXCL12HPGDL3MBTL1HTT | |
| SCHEMBL8363005 | 0.78 | NPC1 (0.60) | L3MBTL1HTTSMN1; SMN2MAPTNOS1 | |
| SCHEMBL10394650 | 0.78 | L3MBTL1 (0.62) | HPGDL3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL5609334 | 0.78 | CXCL12 (0.39) | HSD17B10CXCL12HPGDL3MBTL1HTT | |
| SCHEMBL1328569 | 0.78 | DHFR (0.47) | HPGDHTTSMN1; SMN2MAPTNOS1 | |
| SCHEMBL18154713 | 0.78 | ALOX5AP (0.43) | HSD17B10CXCL12HPGDHTTSMN1; SMN2 | |
| SCHEMBL16056837 | 0.77 | CYP2A6 (0.43) | HSD17B10HPGDHTTSMN1; SMN2MAPT | |
| SCHEMBL11047508 | 0.77 | CXCL12 (0.42) | HSD17B10CXCL12HPGDL3MBTL1HTT | |
| SCHEMBL10978019 | 0.77 | HPGD (0.41) | HSD17B10CXCL12HPGDL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707001-A1 | Benzyloxypyrimidine derivative, processes for producing the same and herbicidal composition | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-04-17 | — | — | EP | claimed |
| US-5128061-A | Phenyl-pyrimidine liquid crystal materials | OPTICAL SHIELDS, INC. (US) | 1992-07-07 | — | — | US | claimed |
| US-4748245-A | Process for making phenylthiopyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1988-05-31 | — | — | US | claimed |
| EP-3322293-B1 | ARYLOXYPYRIMIDINYL ETHERS AS HERBICIDES | FMC CORP (US) | 2021-05-19 | — | — | EP | disclosed |
| US-20150266836-A1 | AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-09-24 | — | — | US | disclosed |
| US-20150266836-A1 | AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-09-24 | — | — | US | disclosed |
| US-20150266836-A1 | AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-09-24 | — | — | US | disclosed |
| US-8846704-B2 | Thiopyrimidine-based compounds and uses thereof | YM Biosciences Austraila Pty Ltd (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2444398-A2 | NOVEL INTERMEDIATES OF VORICONAZOLE AND PREPARATION METHOD OF VORICONAZOLE USING THE SAME | Boryung Pharmaceutical Co., Ltd (KR) | 2012-04-25 | — | — | EP | disclosed |
| US-20100239631-A1 | THIOPYRIMIDINE-BASED COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY LTD | 2010-09-23 | — | — | US | disclosed |
| US-20090181980-A1 | Synergistic Pharmaceutical Composition | ASTRAZENECA AB (SE) | 2009-07-16 | — | — | US | disclosed |
| US-4888047-A | FOR ANNUAL AND PERENNIAL GRASSES AND BROADLEAF WEEDS; POSTEMERGENCE | ICI AMERICAS INC. (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0315889-A2 | Pyrimidine derivatives, processes for their production, and herbicidal method and compositions | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1989-05-17 | — | — | EP | disclosed |
| US-4748245-A | Process for making phenylthiopyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| US-4748245-A | Process for making phenylthiopyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| US-4748245-A | Process for making phenylthiopyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0219835-A2 | Acylaminoaryloxy and arylthio pyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1987-04-29 | — | — | EP | disclosed |
| US-4371736-A | Herbicidal pyridinyloxy(pyrimidinyloxy)benzenes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-02-01 | — | — | US | disclosed |
| EP-0061913-A2 | Herbicidal heterooxybenzenes | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-10-06 | — | — | EP | disclosed |
| US-4248618-A | Derivatives of (pyrimidyloxy)phenoxy-alkanecarboxylic acid and herbicidal compositions thereof | ICI AUSTRALIA LIMITED (AU) | 1981-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266836-A1 | AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF | AHR, CBS, ARSA | HSD17B10 1060/4885CXCL12 2577/4885HPGD 1241/4885 |
| US-20100239631-A1 | THIOPYRIMIDINE-BASED COMPOUNDS AND USES THEREOF | JAK3, JAK1, JAK2 | HSD17B10 3210/4885CXCL12 715/4885HPGD 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.